Leishmania as carriers for the delivery of proteins and peptides
US7261887B2 · kind B2 · utility
4Cited by
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15Claims
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Key dates
| Filing date | Nov 12, 2002 |
| Grant date | Aug 28, 2007 |
| Priority date | — |
| Expiry date | Nov 18, 2022 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for delivering potentially therapeutic or prophylactic protein and peptide agents to mammalian cells are provided. The agents are delivered by mutant trypanosomatid protozoa that have been genetically manipulated to code for such protein or peptide agents. The mutant protozoa additionally lack certain enzymes within the heme biosynthetic pathway, making the mutants susceptible to porphyria and eventual lysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.