Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US7262020B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jun 17, 2004 |
| Grant date | Aug 28, 2007 |
| Priority date | — |
| Expiry date | Jun 17, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to techniques for measuring and comparing relative molecular flux rates of different biological molecules by administering isotope-labeled water to one or more tissues or individuals and comparing the molecular flux rates of two or more biological molecules, including biological molecules in different chemical classes. The methods find use in several applications including diagnosing, prognosing, or monitoring a disease, disorder, or condition, the in vivo high-throughput screening of chemical entities and biological factors for therapeutic effects in various disease models, and the in vivo high-throughput screening of chemical entities and biological factors for toxic effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.