Substituted 5-membered n-heterocyclic compounds and their uses for treating or preventing neurodegenerative diseases

US7262183B2 · kind B2 · utility

Assignees

• Institute of Pharmacology and Toxicology · CN
• Academy of Military Medical Sciences · CN

Inventors

• Song Li · Beijing, CN
• Liqin Zhao · Los Angeles, US
• Lili Wang · Beijing, CN
• Beifen Shen · Beijing, CN
• Liuhong Yun · Beijing, CN

Key dates

• Filing date: Dec 5, 2002
• Grant date: Aug 28, 2007
• Expiry date: Mar 13, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to substituted 5-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, R3, R4, V, W, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases (FKBPs) activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases.