Method for screening combinational bead library; ligands for cancer cells
US7262269B2 · kind B2 · utility
29Cited by
10References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 8, 2003 |
| Grant date | Aug 28, 2007 |
| Priority date | — |
| Expiry date | Oct 8, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54313
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention includes a cell-growth-on-bead assay for screening a one-bead-one-compound combinatorial bead library to identify synthetic ligands for cell attachment and growth or proliferation of epithelial and non-epithelial cells. Cells are incubated with a compound bead library for 24 to 72-hours, allowing them to attach and grow on the beads. Those beads with cells growing are removed, and the ligand on the bead is identified. Also provided are ligands specific for cancer cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.