Process for the synthesis of indanylamine or aminotetralin derivatives and novel intermediates
US7262326B2 · kind B2 · utility
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Key dates
| Filing date | Sep 7, 2005 |
| Grant date | Aug 28, 2007 |
| Priority date | — |
| Expiry date | Sep 7, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C251/66
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing indanylamine and aminotetralin derivatives from indanone or tetralone oximes by acylating the oximes with an organic anhydride, followed by catalytic hydrogenation in the presence of an organic anhydride with subsequent hydrolysis is described. The process is commercially feasible providing indanylamine and aminotetralin derivatives in high yield that are useful as intermediates in the production of therapeutically active compounds. Also described are novel intermediates, 1-indanone O-acetyl oximes and 1-tetralone O-acetyl oximes.
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