Transgenic animal

US7262336B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Kathleen Young · Newtown, US
• David S. Howland · Exton, US
• Karen L. Marquis · Yardley, US
• Sharon Rosenzweig-Lipson · East Brunswick Township, US
• Mark Ian Cockett · Maidenhead, GB

Key dates

• Filing date: Apr 24, 2001
• Grant date: Aug 28, 2007
• Expiry date: May 2, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/85
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A transgenic rat containing in its genome a nucleotide sequence encoding a Ga subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein is eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.