Numb protein expression inhibitors by Musashi
US7264793B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 22, 2001 |
| Grant date | Sep 4, 2007 |
| Priority date | — |
| Expiry date | Nov 6, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An Numb protein expression inhibitor comprising, as active ingredient, Musashi protein, a polypeptide having an amino acid sequence obtained by replacement, deletion, addition or insertion of at least one amino acid in an amino acid sequence of Musashi protein, or a gene encoding said polypeptide.By the present invention, a new function of Musashi protein has been elucidated. Described specifically, Musashi protein inhibits expression of Numb protein having a neuronal differentiation regulating function and potentiates the activity of the Notch signaling system, so that Musashi protein can be used as a therapeutic for various diseases of the central nervous system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.