Polymorphic and amorphous forms of the phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-ce]indol-6-one

US7268126B2 · kind B2 · utility

Assignees

• Agouron Pharmaceuticals, Inc. · US
• Cancer Research Technology Limited · GB

Inventors

• Jia Liu · San Diego, US
• Naresh Nayyar · San Diego, US
• Ming Guo · Suzhou, CN
• Zhen Wu · Lo Wu, CN
• Bennett C. Borer · San Diego, US
• Aparna Nadig Srirangam · San Diego, US
• Mark Mitchell · Morrisville, US
• Yi Li · Shanghai, CN
• Jan-Jon Chu · Carlsbad, US

Key dates

• Filing date: Sep 21, 2005
• Grant date: Sep 11, 2007
• Expiry date: Sep 21, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel polymorphic and amorphous forms of a phosphate salt of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, and to processes for their preparation. Such polymorphic forms may be a component of a pharmaceutical composition and may be used to treat a mammalian disease condition mediated by poly(ADP-ribose) polymerase activity including the disease condition such as cancer.