Modified growth hormone

US7271150B2 · kind B2 · utility

Assignee

• THE UNITED STATES OF AMERICA, represented by the Secretary, Department of Health and Human Services · US

Inventors

• Yoke Peng Loh · Bethesda, US
• Niamh Cawley · Bethesda, US
• Bruce Baum · Bethesda, US
• Christopher R. Snell · Dereham, GB

Key dates

• Filing date: May 14, 2002
• Grant date: Sep 18, 2007
• Expiry date: Jun 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2799/022
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a growth hormone (GH) in which amino acids within the regulated secretory pathway (RSP) sorting signal have been mutated as well as a GH in which the three-dimensional conformation of the RSP sorting signal has been altered, and a composition comprising an effective amount of such a GH in an excipient.