Immunostimulatory nucleic acids

US7271156B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• COLEY PHARMACEUTICAL GMBH · DE

Inventors

• Arthur M. Krieg · Wellesley, US
• Jorg Vollmer · Goldkronach, DE
• Christian Schetter · Hilden, DE

Key dates

• Filing date: Dec 9, 2002
• Grant date: Sep 18, 2007
• Expiry date: Dec 9, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich nucleic acids have at least one poly-C region and/ore greater than 50% c nucleotides. These immunostimulatory nucleic acids function in a similar manner to nucleic acids containing CpG motifs. The invention also encompasses preferred CpG nucleic acids.