Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands

US7271170B2 · kind B2 · utility

Assignee

• Neurogen Corporation · US

Inventors

• Linghong Xie · Guilford, US
• Bingsong Han · Westwood, US
• Yuelian Xu · Zhejiang, CN
• George D. Maynard · Clinton, US
• Bertrand L. Chenard · Waterford, US
• Kenneth Shaw · Weston, US
• Yang Gao · Hangzhou City, CN

Key dates

• Filing date: Jul 23, 2004
• Grant date: Sep 18, 2007
• Expiry date: Jan 15, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula Iare provided, as are methods for their preparation. The variables Z1, Z2, Z3, R4, R5, R6, R7, R8 and Ar in the above formula are defined herein. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).