Triggered release of liposomal drugs following mixing of cationic and anionic liposomes
US7273620B1 · kind B1 · utility
17Cited by
27References
14Claims
0Family size
Assignee
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Key dates
| Filing date | May 19, 2003 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Mar 2, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1272
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for triggering the delivery of an encapsulated therapeutic agent from a liposome are provided. Liposomes of opposite charge and incorporating lipids which favor non-lamellar structures are contacted in vivo. At least one of the liposome encapsulates at least one therapeutic drug or agent. Preferably, the liposomes have a fusogenic hydrophillic coating, such as PEG to control the rate of interaction of the liposomes and release of the therapeutic agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.