Detection of mutations
US7273703B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 9, 2003 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Jan 9, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/0073
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a polypeptide which is a flavin-containing monooxygenase 3 (FMO3), wherein said FMO3 is a polypeptide comprising at least a sequence having at least 85% identity with the polypeptide sequence SEQ ID NO: 15, in particular to a polypeptide which is a functionally altered mutant of flavin-containing mono oxygenase 3 (FMO3) leading to a buildup of trimethylamine in an animal. Further, the invention relates to nucleic acid sequences encoding said polypeptide, and to the complements of such nucleic acid sequences. Such nucleic acid sequences and fragments thereof may be useful e.g. as primers. The invention further relates to various methods for determining the presence in e.g. a nucleic acid sample of a nucleic acid sequence encoding a mutated FMO3 polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.