Method of identifying a modulator of a LTβR complex signaling pathway
US7273707B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 10, 2003 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Dec 24, 2023 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2510/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates to compositions and methods comprising lymphotoxin-beta receptor (LTβR) modulators, which activate or inhibit LTβR signaling. LTβR modulators are useful for treating lymphocyte mediated immunological diseases and cancer, and more particularly, for regulating mitochondrial-mediated apoptosis. This invention relates to soluble forms of the LTβR complex proteins that act as LTβR activating or inhibiting agents. This invention also relates to the use of soluble molecules, directed against either the LTβR, its ligands, LIGHT and LTβ1α2, or its intracellular binding partners, that function to regulate LTβR signaling. A novel screening method for selecting soluble receptors, antibodies and other agents that modulate LTβR signaling is provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.