Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
US7273881B2 · kind B2 · utility
6Cited by
15References
12Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jan 13, 2005 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Jan 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A class of novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I)its stereoisomers thereof, or a solvate thereof, or a pharmaceutically acceptable salt thereof, where Z is S, O or NH; and R, R1, R2 Ra, Rb, Rc, Rd, Z, A and B are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.