Process of preparing esters and ethers of probucol and derivatives thereof
US7273948B2 · kind B2 · utility
2Cited by
16References
55Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 2004 |
| Grant date | Sep 25, 2007 |
| Priority date | — |
| Expiry date | Mar 26, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C319/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different from that on the parent probucol molecule but which maintains the two free hydroxyl groups) with a Grignard reagent or a lithium reagent that produces a magnesium bromide or lithium salt of probucol or the probucol derivative. The probucol compound anion anion is then reacted with an ester or ether forming compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.