Methods for treating hematological disorders through inhibition of DNA methylation and histone deacetylase
US7276228B2 · kind B2 · utility
10Cited by
7References
16Claims
0Family size
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Key dates
| Filing date | Mar 15, 2005 |
| Grant date | Oct 2, 2007 |
| Priority date | — |
| Expiry date | Mar 15, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods are provided for treating hematological disorders by inhibition of DNA hypomethylation and histone deacetylase. Such disorders include, for example, acute promyelocytic leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, myelodysplastic syndromes, and sickle cell anemia. The methods comprise: administering to a patient suffering from the disease a therapeutically effective amount of a DNA methylation inhibitor such as a cysteine analog such as decitabine, in combination with an effective amount of histone deacetylase inhibitor such as hydroxamic acid, cyclic peptide, benzamide, butyrate, and depudecin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.