Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein
US7276344B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 25, 2004 |
| Grant date | Oct 2, 2007 |
| Priority date | — |
| Expiry date | Jan 22, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P19/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis, respectively.The protein can be isolated and purified from culture medium of the said fibroblasts. Furthermore, the protein can be produced by gene engineering.The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity to the protein or a method for determination of the protein concentration using the antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.