Nucleotide analogs with six-membered rings

US7276592B2 · kind B2 · utility

Assignee

• Roche Diagnostics Operations, Inc. · US

Inventors

• Frank Bergmann · Iffeldorf, DE
• Horst Donner · Munich, DE
• Herbert von der Eltz · Spaichingen, DE
• Dieter Heindl · Munich, DE
• Piet Herdewijn · Wezemaal, BE

Key dates

• Filing date: Apr 1, 2004
• Grant date: Oct 2, 2007
• Expiry date: Aug 4, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is related to compounds comprising six-membered rings capable of being incorporated into nucleic acids. Particularly, the six-membered ring is a derivative of cyclohexane, cyclohexene, tetrahydropyran, tetrahydrothiopyran or piperidine. These compounds may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods for the detection of nucleic acids are provided wherein the oligomeric compounds are used.