Methods for increasing the resistance of a host cell to aromatic carboxylic acids
US7279321B2 · kind B2 · utility
0Cited by
5References
9Claims
0Family size
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Key dates
| Filing date | Jan 16, 2004 |
| Grant date | Oct 9, 2007 |
| Priority date | — |
| Expiry date | Jun 8, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/245
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides methods of increasing the production of aromatic carboxylic acids from a host cell via manipulation of the yhcRQP operon encoding a family of efflux proteins. Up-regulation of all or a sub-set of the genes in the yhcRQP were additionally found to enhance tolerance to aromatic carboxylic acids toxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.