Nucleic acid encoding G-protein coupled receptor with modified DRY motif
US7279324B2 · kind B2 · utility
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22References
9Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 22, 2002 |
| Grant date | Oct 9, 2007 |
| Priority date | — |
| Expiry date | May 6, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to modified G-protein coupled receptors (GPCRs). The modified GPCRs of the present invention include GPCRs that have been modified to have altered DRY motifs such that the modified GPCRs are constitutively desensitized. As such, the modified GPCRs of the present invention preferably localize to endocytic vesicles or endosomes in an agonist-independent manner. The invention also relates to methods of screening compounds and sample solutions for GPCR activity using the modified GPCRs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.