Therapeutic agents useful for treating pain

US7279493B2 · kind B2 · utility

Assignee

• Euro-Celtique S.A. · LU

Inventors

• Donald J. Kyle · Yardley, US
• Qun Sun · Princeton, US
• Laykea Tafesse · Robinsville, US
• Chongwu Zhang
• Xiaoming Zhou · Plainsboro, US

Key dates

• Filing date: Jun 27, 2003
• Grant date: Oct 9, 2007
• Expiry date: Oct 24, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D333/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of formula:wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective amount of a Cyanoiminopiperazine Compound, and methods for treating or preventing pain, urinary incontinence, an ulcer, inflammatory-bowel disease, irritable-bowel syndrome, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia or depression in an animal comprising administering to an animal in need thereof an effective amount of a Cyanoiminopiperazine Compound are disclosed.