Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US7279502B2 · kind B2 · utility
11Cited by
147References
6Claims
0Family size
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Key dates
| Filing date | Oct 20, 2004 |
| Grant date | Oct 9, 2007 |
| Priority date | — |
| Expiry date | Oct 20, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.