Micro-well and methods of fabricating and selectively blackening the same
US7280727B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2004 |
| Grant date | Oct 9, 2007 |
| Priority date | — |
| Expiry date | Sep 7, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/08
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Well plates adaptable for specimen sampling in the biological, chemical and pharmaceutical sciences are fabricated by dissolving fusedly-retained cores from the cladding material of a fused fiber plate to define a capillary plate including first and second faces and a plurality of through-voids into which fluidic samples may be deposited for analysis. Closed-bottom wells are defined by bonding one of the first and second faces to a base plate or by securing into well-sealing positions over the open ends of selected through-voids optical elements, each of which optical elements exhibits a predetermined optical property. Cladding material including reducible ions is exposed to a reduction atmosphere in order to blacken selected regions of a well plate, thereby enhancing sample analysis by reducing such disadvantageous phenomena as autofluorescence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.