pH sensitive polymer for inhibiting transformation in drugs
US7282218B2 · kind B2 · utility
9Cited by
7References
42Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2003 |
| Grant date | Oct 16, 2007 |
| Priority date | — |
| Expiry date | Aug 21, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a substantially amorphous pharmaceutical composition comprising a drug that can exist in a variety of polymorphic forms and a pH sensitive polymer, which inhibits the crystallization of the drug during formulation and reconstitution. Polymers of higher molecular weight are more effective at lower loading, especially when the drug polymer matrix is prepared by the solvent evaporation or solvent extraction technique. The compositions used as dry syrups maintain bioavailability of the drug and effectively mask the taste of the drug when the composition is reconstituted.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.