Small molecule inhibitors of rotamase enzyme activity
US7282510B2 · kind B2 · utility
2Cited by
59References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 27, 2005 |
| Grant date | Oct 16, 2007 |
| Priority date | — |
| Expiry date | Jun 27, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.