Dithiocarbamate antiviral agents and methods of using same

US7282599B2 · kind B2 · utility

Assignee

• Avir Green Hills Biotechnology Research Development Trade AG · AT

Inventors

• Elisabeth Gaudernak · Wien, AT
• Andreas Grassauer · Wien, AT
• Ernst Kuchler · Wien, AT
• Thomas Muster · Wien, AT
• Joachim Seipelt · Wien, AT

Key dates

• Filing date: Jul 15, 2002
• Grant date: Oct 16, 2007
• Expiry date: Sep 29, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention discloses a use of dithiocarbamate compounds having the structural formula R1R2NCS2H, in which R1 and R2, independently of each other, represent a straight or branched C1-C4 alkyl, or, with the nitrogen atom, form an aliphatic ring with 4 to 6 C atoms, in which R1, R2, or the aliphatic ring is optionally substituted with one or more substituents selected from OH, NO2, NH2, COOH, SH, F, Cl, Br, I, methyl or ethyl, and oxidized forms of these compounds, in particular dimers thereof, as well as pharmaceutically acceptable salts thereof, to prepare an agent for treating or preventing an infection by RNA viruses which attack the respiratory tract and cause disease there.