Raman-active particles and methods of making and using them
US7285427B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Oct 6, 2004 |
| Grant date | Oct 23, 2007 |
| Priority date | — |
| Expiry date | Jun 29, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/587
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A Raman-active particle as well as a method of making a Raman-active particle are described. The Raman-active particle includes a core particle and a coating. The coating substantially covers the core particle. A Raman-active analyte is at least partially within the coating. The method of making a Raman-active particle includes i) providing a colloidal solution comprising a core particle; ii) providing a coating or coating precursor to the colloidal solution to form a resulting solution; and iii) providing a Raman-active analyte to the resulting solution. A method of conducting an assay is also described. The method includes: i) attaching a Raman-active particle to a targeted moiety; ii) measuring the Raman spectrum of the Raman-active particle; and iii) correlating the Raman spectrum to the presence of the targeted moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.