Embedder compositions and methods for detecting and killing cells in acidic areas of tumors
US7285529B2 · kind B2 · utility
6Cited by
1References
22Claims
0Family size
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Key dates
| Filing date | Feb 28, 2005 |
| Grant date | Oct 23, 2007 |
| Priority date | — |
| Expiry date | Sep 13, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/544
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Embedder compositions effective for detecting or killing cells in acidic areas of tumors are described. Each composition includes an embedder peptide which at pH 7.2 and above is poly-anionic and so repels from cells in normal tissues, but at lower pH in hypoxic areas of tumors the embedder peptide converts to a non-ionic lipophilic form effective to embed into membranes of cells. Each composition also includes a cargo component which cannot be pulled across cell membranes by the embedder peptide and which is effective for detecting or killing cells in whose membranes the embedder peptide has embedded.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.