Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US7285665B2 · kind B2 · utility
11Cited by
19References
50Claims
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Key dates
| Filing date | Nov 5, 2003 |
| Grant date | Oct 23, 2007 |
| Priority date | — |
| Expiry date | Apr 21, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of a quaternary derivative of the morphinan alkaloid, the process comprising contacting a tertiary N-substituted morphinan alkaloid with an alkyl halide in an anhydrous solvent system, wherein the solvent system comprises an aprotic dipolar solvent with the aprotic dipolar solvent constituting at least 25 wt. % of the solvent system.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.