Process for preparing 2,6-diamino-4,5,6,7-tetrahydro-benzothiazole
US7285669B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Nov 3, 2003 |
| Grant date | Oct 23, 2007 |
| Priority date | — |
| Expiry date | Nov 3, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D277/82
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
2,6-diamino-4,5,6,7-tetrahydro-benzothiazole, which is useful for making pramipexole, is made by: (i) reacting bromine with a solution of 4-acetamido-cyclohexanone in water to produce 2-bromo-4-acetamido-cyclohexanone; (ii) after step (i), adding thiourea to produce 6-acetyl amino-2-amino-4,5,6,7-tetrahydro-benzthiazole; (iii) after step (ii), adding an aqueous solution of hydrobromic acid to produce 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole dihydrobromide; and (iv) after step (iii), isolating 2,6-diamino-4,5,6,7-tetrahydro-benzthiazole.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.