Silane molecules with pre-activated and protein-resistant functionalities and silane films comprising such molecules
US7285674B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 3, 2005 |
| Grant date | Oct 23, 2007 |
| Priority date | — |
| Expiry date | Jul 27, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/552
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides a silane molecule which combines pre-activated and protein-resistant functionalities in one molecule; the molecule has a general formula:A-(CH2)n—(O[CH2]t)m—(CH2)v—Y (1)wherein A is a functional group for binding to a substrate and Y is a functional group for binding to biomolecules. The invention furthermore provides a method for the synthesis of such a silane molecule and a method for depositing a monolayer of such silane molecules onto a substrate. Such a monolayer of silane molecules may be used in biosensors, DNA/protein micro-arrays or other sensor applications. For further lowering the protein binding to the surface of the biosensor, the monolayer may furthermore comprise second silane molecules with formula:B—(CH2)o—(OCH2CH2)r—Z. (4)
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.