Homogeneity and secretion of a recombinant follicle stimulating hormone (FSH) in mammalian systems
US7291339B2 · kind B2 · utility
0Cited by
7References
20Claims
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Key dates
| Filing date | Dec 1, 2003 |
| Grant date | Nov 6, 2007 |
| Priority date | — |
| Expiry date | Jun 30, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A hybrid protein includes two coexpressed amino acid sequences forming a dimer. Each sequence contains the binding portion of a receptor, such as TBP1 or TBP2, or a ligand, such as IL-6, IFN-β and TPO, linked to α subunit of a natural heterodimeric scaffold. Each coexpressed sequence contains a corresponding subunit so as to form a heterodimer upon expression. Corresponding DNA molecules, expression vectors and host cells are also disclosed as are pharmaceutical compositions and a method of producing such proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.