Anti-dermatophytic preparation and use thereof

US7291349B2 · kind B2 · utility

Inventors

• Suman Preet Singh Khanuja · Lucknow, IN
• Pushplata Chaturvedi · Sidhauli, IN
• Anil Kumar Singh · Lucknow, IN
• Ajit Kumar Shasany · Sidhauli, IN
• Vinay Kumar Agarwal · Sidhauli, IN
• Vivek Gupta · San Jose, US
• Subhash Chandra Gupta · Lucknow, IN
• Arun Kumar Tripathy · New Delhi, IN
• Anirban Pal · Lucknow, IN
• Dharmendra Saikia · Lucknow, IN
• Mahendra Pandurang Darokar · Lucknow, IN
• Krishna Kumar Aggarwal · Sidhauli, IN
• Ravi Bansal · Lucknow, IN

Key dates

• Filing date: Jan 21, 2004
• Grant date: Nov 6, 2007
• Expiry date: Jul 17, 2024

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K36/8962
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.