Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA
US7291486B2 · kind B2 · utility
1Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Apr 21, 2004 |
| Grant date | Nov 6, 2007 |
| Priority date | — |
| Expiry date | Dec 30, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/62
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces cinnamonensis as well as Propionibacterium shermanii epimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-type E. coli host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.