5-substituted 1,1-dioxo-1,2,5,-thiadiazolidin-3-one derivatives
US7291635B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 2, 2003 |
| Grant date | Nov 6, 2007 |
| Priority date | — |
| Expiry date | Jun 12, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06078
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compounds of the formulaprovide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditions associated with PTPase activity. The compounds of the present invention may also be employed for inhibition of other enzymes with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula I may be employed for prevention or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels. The compounds of the present invention may also be employed in the treatment, prevention or control of a number of conditions that accompany Type 2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat or prevent cancer, osteoporosis, neurodegenerative and infectious…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.