Bradykinin-B1 antagonists, process for their preparation and their use as medicaments

US7291642B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Iris Kauffmann-Hefner · Biberach an der Riß, DE
• Norbert Hauel · Schemmerhofen, DE
• Henri Doods · Warthausen, DE
• Angelo Ceci · Mittelbiberach, DE
• Stefan Peters · Biberach an der Riß, DE

Key dates

• Filing date: Oct 21, 2005
• Grant date: Nov 6, 2007
• Expiry date: Apr 22, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides bradykinin-B1 antagonists of the formulain which A, Ar, G, Q, R1 and R4 are as defined in claim 1, their enantiomers, their diastereomers, their mixtures and their salts, in particular their physiologically acceptable salts with organic or inorganic acids or bases having useful properties, their preparation, medicaments comprising the pharmacologically effective compounds, their preparation and their use.