Functional assays for identifying compounds that modulate T1R2/T1R3 (sweet) taste
US7294474B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 3, 2003 |
| Grant date | Nov 13, 2007 |
| Priority date | — |
| Expiry date | May 29, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Functional assays for identifying compounds that activate or modulate the activation of the T1R2/T1R3 (sweet) taste receptor are provided. These assays detect the effect of one or more compounds on the activation of T1R2/T1R3 (sweet) taste receptor or on the activation of T1R2/T1R3 sweet taste receptor by another, compound e.g., saccharin or another artificial or natural sweetener. These assays preferably are cell-based functional assays and typically use cells, e.g., HEK-293 cells that stably express a G protein such as Gα15, Gα16 or gustducin. Compounds identified in the disclosed functional assays are potentially useful as additives in compositions for human or animal consumption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.