Synthesis of a 4-methylthiazole-4(S)-carboxylic acid compound
US7294718B2 · kind B2 · utility
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12References
6Claims
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Key dates
| Filing date | Dec 9, 2004 |
| Grant date | Nov 13, 2007 |
| Priority date | — |
| Expiry date | Jun 8, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Benzimidates can be reacted with a large number of nucleophiles, leading to a wide variety of products. The present invention discloses a facile synthesis for ethyl 2,4-dihydroxybenzimidate, and ethers and diethers thereof, from 2,4-dihydroxybenzoic acid or 2,4-dibenzyloxybenzoic acid. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, 2,4-dihydroxybenzonitrile is condensed with (S)-2-methylcysteine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.