Patent · US Expired

Process for manufacturing of enantiomerically pure 3-hydroxy-3-phenyl-propylamin

US7294744B2 · kind B2 · utility

1Cited by

5References

17Claims

0Family size

Assignee

BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

Wolfgang Baumgarten · Gau-Algesheim, DE
Robert Schiffers · Gau-Algesheim, DE

Key dates

Filing date	Jun 30, 2005
Grant date	Nov 13, 2007
Priority date	—
Expiry date	Mar 1, 2026

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C213/00
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to an improved process for preparing enantiomerically pure 3-hydroxy-3-phenyl-propylamines on an industrial scale using asymmetrical hydrogenation as a key step and optionally a special sequence of subsequent steps, using a catalyst system consisting of rhodium and chiral 4-(dicyclohexylphosphino)-2-(diphenyl-phosphino-methyl)-N-methyl-aminocarbonyl-pyrrolidine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.