Biodegradable triblock copolymers, synthesis methods therefore, and hydrogels and biomaterials made there from
US7297348B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 18, 2003 |
| Grant date | Nov 20, 2007 |
| Priority date | — |
| Expiry date | Jun 20, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/802
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.