Fibroblast growth factor receptor activating gene 1 and related compositions and methods

US7297493B2 · kind B2 · utility

Assignee

• The Government of the United States of America as represented by the Secretary of the Deptartment of Health and Human Services · US

Inventors

• Matthew Lorenzi · Philadelphia, US
• Toru Miki · North Bethesda, US

Key dates

• Filing date: Nov 18, 2004
• Grant date: Nov 20, 2007
• Expiry date: Jan 6, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A novel gene designated as FRAG1 from and its encoded protein is disclosed. A fusion protein called FGFR2-ROS, which is formed by chromosomal rearrangement of rat FRAG1 with FGFR2 is also disclosed. Methods of producing FRAG1 protein, related fusion proteins, and antibodies against FRAG1 are disclosed, as are related pharmaceuticals and methods of using such nucleic acids, polypeptides, and antibodies are also disclosed.