Substituted 1-propiolylpiperazine compounds, their preparation and use

US7300939B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Sven Kuehnert · Lehrte, DE
• Stefan Oberboersch · Aachen, DE
• Michael Haurand · Aachen, DE
• Ruth Jostock · Stolberg, DE
• Klaus Schiene · Goldkronach, DE

Key dates

• Filing date: Jan 4, 2007
• Grant date: Nov 27, 2007
• Expiry date: Jan 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted 1-propiolylpiperazine compounds corresponding to formula Iin which X denotes N or C—R2, and n is an integer from 0 to 8, a method for producing such substituted 1-propiolylpiperazine compounds, pharmaceutical compositions containing such substituted 1-propiolylpiperazine compounds, and the use of such substituted 1-propiolylpiperazine compounds for modulating mGluR5 receptor activity or for treating or inhibiting pain and various other conditions, especially conditions at least partly mediated by the mGluR5 receptor.