Patent · US Expired

Pyrazole derivatives, their preparation and their use in pharmaceuticals

US7300950B2 · kind B2 · utility

7Cited by

8References

7Claims

0Family size

Assignee

Aventis Pharma Deutschland GmbH · DE

Inventors

Ursula Schindler · Bad Soden, DE
Karl Schonafinger · Alzenau, DE
Hartmut Strobel · Liederbach, DE

Key dates

Filing date	Apr 13, 2005
Grant date	Nov 27, 2007
Priority date	—
Expiry date	Apr 13, 2025

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D409/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to pyrazole derivatives of the formula I, their preparation and their use in pharmaceuticals:in which X, R1, R1a, R2, R3, R4 and n are as defined in the claims, which are useful pharmaceutically active compounds for the therapy and prophylaxis of illnesses, for example of cardiovascular diseases such as hypertension, angina pectoris, cardiac insufficiency, thromboses or atherosclerosis. The compounds of the formula I are capable of modulating the body's production of cyclic guanosine monophosphate “cGMP” and are generally suitable for the therapy and prophylaxis of illnesses which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of the formula I, to their use for the therapy and prophylaxis of the abovementioned illnesses and for preparing pharmaceuticals for this purpose, and also to pharmaceutical preparations which comprise the compounds of the formula I.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.