Method for creating specific, high affinity nuclear receptor pharmaceuticals

US7302347B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• John D. Baxter · West Melbourne, US
• Thomas S. Scanlan · San Francisco, US
• Robert J. Fetterick · Hillsborough, US
• Sabine Borngraeber · San Francisco, US
• Paul Webb · Leeds, GB

Key dates

• Filing date: Dec 10, 2002
• Grant date: Nov 27, 2007
• Expiry date: Apr 26, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S707/99943
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention pertains to agonists that activate nuclear receptors. These agonists include an extension that contacts a region of the nuclear receptor outside the native ligand binding pocket. Methods for producing, identifying and designing such agonists are included along with nuclear receptor agonist complexes and libraries of agonists.