Anti-plasmodium compositions and methods of use

US7303751B2 · kind B2 · utility

Assignee

• The Government of the United States of American, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• David Narum · Gaithersburg, US
• Kim Lee Sim · Gaithersburg, US

Key dates

• Filing date: Jul 29, 2003
• Grant date: Dec 4, 2007
• Expiry date: Oct 26, 2024

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions that inhibit the binding of Plasmodium falciparum to erythrocytes include a family of erythrocyte binding proteins (EBPs). The EBPs are paralogues of the P. falciparum binding protein EBA-175. The present invention includes peptides of the paralogues that prevent the binding of P. falciparum. Antibodies specific for each paralogue that also prevent the binding of P. falciparum are also included. Methods of the invention utilize the paralogues, antibodies thereof and peptide compositions for the diagnosis, prevention, and treatment of P. falciparum diseases such as malaria, as well as methods for the detection of P. falciparum in biological samples and culture media.