Screening method for candidate drugs

US7303885B1 · kind B1 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Herwig Brunner · Stuttgart, DE
• Jurgen Bernhagen · Tübingen, DE
• Robert Kleemann · Delft, NL
• Ralf Mischke · Biberach, DE
• Afroditi Kapurniotu · Aachen, DE

Key dates

• Filing date: Nov 2, 2000
• Grant date: Dec 4, 2007
• Expiry date: Aug 8, 2022

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to methods for screening molecules and methods to detect protein-protein interactions and means used therein. More specifically, the present invention relates to methods for screening candidate drugs for treating or detecting MIF (macrophage migration inhibitor factor) related diseases. In certain aspects, the present invention involves detecting MIF/Jab1 (c-Jun activation domain binding protein) interactions as a basis for modulating cellular regulatory pathways and for identifying candidate drugs for MIF-related diseases. The invention also provides methods for the identification of molecules which dissociate or prevent interaction or binding between MIF and Jab1.