Substituted 6-membered N-heterocyclic compounds and method for their use as neurological regulator

US7304057B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Song Li · Beijing, CN
• Aihua Nie · Beijing, CN
• Beifen Shen · Beijing, CN
• Lili Wang · Beijing, CN
• Wuhong Pei · Beijing, CN
• Junhai Xiao · Beijing, CN
• Songcheng Yang · Beijing, CN
• Liuhong Yun · Beijing, CN
• Hongying Liu · Beijing, CN
• Cuiling Shu · Beijing, CN
• Hongxia Wang · Thompson Drive, CN
• Zihe Rao · Beijing, CN

Key dates

• Filing date: Dec 5, 2002
• Grant date: Dec 4, 2007
• Expiry date: Sep 1, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to substituted 6-membered N-Herterocyclic neurotrophic compounds of formula (I) or pharmaceutically acceptable salts or hydrates thereof, wherein R1, R2, X, Y, and Z are as defined in the description; their preparation methods, compositions comprising the same, and their use as inhibitors of FK560 binding proteases activity for treating and preventing neurodegenerative diseases and other nerve disorders associated with nerve injuries or other related diseases