Patent · US Expired

Method for detecting carcinomas in a solubilized cervical body sample

US7306926B2 · kind B2 · utility

10Cited by

6References

14Claims

0Family size

Assignee

MTM Laboratories, AG · DE

Inventors

Magnus Von Knebel Doeberitz · Heidelberg, DE
Rudiger Ridder · Schriesheim, DE
Matthias Herkert · Heidelberg, DE
Anja Reichert · Schallstadt, DE

Key dates

Filing date	Aug 26, 2003
Grant date	Dec 11, 2007
Priority date	—
Expiry date	Dec 13, 2024

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/4739
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention relates to a method for the early diagnosis of carcinomas and their preliminary stages, which comprises determining the overexpression of a cell cycle regulatory protein in a solubilized body sample. The present invention is particularly directed to a method for detecting cervical carcinomas, cervical intraepithelial neoplasias, or cervical carcinomas in-situ from a solubilized cervical body sample of a human subject, by solubilizing the cervical body sample in a lysis buffer, and determining the overexpression of cyclin dependent kinase inhibitor p16 in the solubilized cervical sample. The invention also concerns a test kit usable for this purpose as well as an in-vitro diagnostic device.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.