Advanced cell-transducing transport domain-target protein-transport domain fusion protein and uses thereof
US7306944B2 · kind B2 · utility
14Cited by
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4Claims
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Key dates
| Filing date | Mar 13, 2003 |
| Grant date | Dec 11, 2007 |
| Priority date | — |
| Expiry date | Dec 24, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16322
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a fusion protein which delivers a functional protein or peptide into a cell at enhanced efficiency. The fusion protein of the present invention is a transduction domain-target protein-transduction domain fusion protein, wherein the transduction domain, which comprises 6-12 amino acid residues whose more than ¾ consist of arginine or lysine residues, is covalently bonded to each of the amino- and carboxyl-terminal ends of the target protein. Green fluorescence protein and Cu/Zn-superoxide dismutate (SOD) are used as the target protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.